Clesrovimab for Prevention of RSV Disease in Healthy Infants
In healthy preterm and full-term infants, a single dose of clesrovimab reduced the incidence of RSV-associated medically attended lower respiratory infection and RSV-associated hospitalization, with a safety profile similar to that of placebo. (Funded by Merck Sharp and Dohme; CLEVER ClinicalTrials.gov number, NCT04767373.).
Authors
- José M. López‐Novoa (ORCID: https://orcid.org/0000-0002-6211-7269)
- Kazushige Ikeda (ORCID: https://orcid.org/0000-0002-3097-2156)
- Radha Railkar
- Jorge A. Piedrahita (ORCID: https://orcid.org/0000-0001-9751-3192)
- Shelly Senders
- Xiaowei Zang (ORCID: https://orcid.org/0000-0002-8319-5303)
- Jeannine Lutkiewicz (ORCID: https://orcid.org/0000-0003-3862-8867)
- Julie S. Shepard
- Marc Dionne (ORCID: https://orcid.org/0000-0002-8283-1750)
- Kamolwish Laoprasopwattana (ORCID: https://orcid.org/0000-0002-6428-2305)
- Kalpit A. Vora (ORCID: https://orcid.org/0000-0001-9844-634X)
- Octavio Ramilo (ORCID: https://orcid.org/0000-0002-0565-5239)
- Teresa Jackowska (ORCID: https://orcid.org/0000-0003-0131-7854)
- Andrew W. Lee
- Brian M. Maas (ORCID: https://orcid.org/0000-0002-2410-4379)
- Shabir Ahmed Madhi (ORCID: https://orcid.org/0000-0002-7629-0636)
- Enmei Liu (ORCID: https://orcid.org/0000-0001-8503-6974)
- Heather Joy Zar (ORCID: https://orcid.org/0000-0002-9046-759X)
- Eric A. F. Simões (ORCID: https://orcid.org/0000-0001-5588-2723)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-2666-6575)
- Sergio L. Vargas (ORCID: https://orcid.org/0000-0002-9369-2856)
- Anushua Sinha
- Andrea Guerra
- Yasunori Ishihara (ORCID: https://orcid.org/0009-0004-8733-8254)
Institutions
- Universidad de Santiago de Chile (CL)
- South African Medical Research Council (ZA)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- St. Jude Children's Research Hospital (US)
- Prince of Songkla University (TH)
- Serviço Nacional de Aprendizagem Industrial (BR)
- University of Cape Town (ZA)
- Centre hospitalier universitaire de Québec (CA)
- Children's Hospital Colorado (US)
- Dayton Clinical Oncology Program (US)
- University of Fukui Hospital (JP)
- University of the Coast (CO)
- Morgan Stanley (United Kingdom) (GB)
- Hospital Padre Hurtado (CL)
- Postgraduate School of Molecular Medicine (PL)
- Saitama Municipal Hospital (JP)
- Children's Hospital of Chongqing Medical University (CN)
- University of Chile (CL)
- Chongqing Medical University (CN)
- University of Colorado Denver (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1056/nejmoa2502984
- Citations
- 28
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 37.92