Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
Aspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with <i>PIK3CA</i> hotspot mutations in exon 9 or 20 and appeared to have a similar benefit among those with other somatic alterations in PI3K pathway genes. (Funded by the Swedish Research Council and others; ALASCCA ClinicalTrials.gov number, NCT02647099; EudraCT number, 2015-004240-19.).
Authors
- Lene H. Iversen
- Martin Janson
- Rebecka Bergström (ORCID: https://orcid.org/0000-0001-7609-0733)
- Ida Hed Myrberg (ORCID: https://orcid.org/0000-0002-8297-2238)
- Henrik Grönberg (ORCID: https://orcid.org/0000-0002-1073-2753)
- Johan Lindberg (ORCID: https://orcid.org/0000-0003-3610-6774)
- Karin Westberg (ORCID: https://orcid.org/0000-0003-3690-5349)
- Bengt Glimelius (ORCID: https://orcid.org/0000-0002-5440-791X)
- Markus Mayrhofer (ORCID: https://orcid.org/0000-0003-3403-0083)
- Tom Öresland
- Mef Nilbert (ORCID: https://orcid.org/0000-0003-2717-1937)
- Eva Angenete (ORCID: https://orcid.org/0000-0001-9966-4904)
- Mattias Prytz (ORCID: https://orcid.org/0000-0002-3939-927X)
- Carola Haapamäki (ORCID: https://orcid.org/0000-0002-6507-3476)
- Anna Martling (ORCID: https://orcid.org/0000-0001-5998-4735)
- Josefin Segelman (ORCID: https://orcid.org/0000-0002-7738-9806)
- Martin Eklund
- Fredrik Granath
- Urban Ersson
Institutions
- Uppsala University (SE)
- Oslo University Hospital (NO)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of Oslo (NO)
- Science for Life Laboratory (SE)
- Akershus University Hospital (NO)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- Danderyds sjukhus (SE)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- Glanrhyd Hospital (GB)
- NU Hospital Group (SE)
- Ersta sjukhus (SE)
- Skåne University Hospital (SE)
- Skaraborg Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1056/nejmoa2504650
- Citations
- 35
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 48.81