Management of infections caused by Extended-spectrum beta-lactamase-producing Enterobacterales in Indian patients
This guidance document highlights the importance of early and accurate identification of ESBL -producing Enterobacterales, outlines clinical syndromes that may require empirical antibiotic coverage for ESBLs, and offers guidance on appropriate de-escalation strategies. Additionally, it emphasizes on the optimal use of use of newer beta-lactam/beta-lactamase inhibitor (BLBLI) combinations, such as cefepime-enmetazobactam and ceftolozane-tazobactam, and also emphasizes on avoiding important drugs like ceftazidime-avibactam for ESBL -producing Enterobacterales.
Authors
- N.K. Bansal (ORCID: https://orcid.org/0000-0001-5403-6293)
- Ram Gopalakrishnan (ORCID: https://orcid.org/0000-0002-2263-1861)
- Pallab Ray (ORCID: https://orcid.org/0000-0003-3369-2640)
- V. Ramasubramanian
- Kamini Walia
- Sonam Vijay
- Rajalakshmi Arjun (ORCID: https://orcid.org/0000-0002-4838-183X)
- George M. Varghese (ORCID: https://orcid.org/0000-0002-4040-5649)
- Vasant Nagvekar
- Balaji Veeraraghavan (ORCID: https://orcid.org/0000-0002-8662-4257)
- Neha Gupta (ORCID: https://orcid.org/0000-0002-3608-9049)
- Priscilla Rupali (ORCID: https://orcid.org/0000-0002-5115-067X)
- Sanjay Bhattacharya (ORCID: https://orcid.org/0000-0003-4139-1039)
- Camilla Rodrigues
Institutions
- Apollo Hospitals (IN)
- Christian Medical College, Vellore (IN)
- Sir H.N. Reliance Foundation Hospital and Research Centre (IN)
- P. D. Hinduja Hospital and Medical Research Centre (IN)
- Indian Council of Medical Research (IN)
- Tata Medical Center (IN)
- Rajiv Gandhi Cancer Institute and Research Centre (IN)
- Fortis Memorial Research Institute (IN)
- Kerala Institute of Medical Sciences (IN)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Indian Journal of Medical Microbiology
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.ijmmb.2025.100974
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00