Expression of LINC01123 in Patients with Hypertension and Its Damage to Endothelial Cells

Hypertension affects nearly 1/4 of the global population.LINC01123 is closely related to cancer and vascular smooth muscle cell function.Its role in hypertension remains unknown.This study aimed to investigate the expression of LINC01123 in patients with hypertension and its damage to endothelial cells.In this study 149 healthy individuals and 149 hypertension patients participated.The expression of LINC01123 and miR-34a-5p was estimated by RT-qPCR.The relationship between LINC01123 and blood pressure, endothelial cell function and miR-34a-5p were analyzed by Pearson correlation analysis.Logistic regression analysis was employed to identify the potential risk factors of hypertension.The regulatory role of LINC01123 was explored in HUVECs.In hypertension group, the significantly elevated LINC01123 was positively associated with SBP (r = 0.5182, P < 0.0001), DBP (r = 0.5904, P < 0.0001), Ang II (r = 0.5614, P < 0.0001) and ET-1 (r = 0.6086, P < 0.0001) while a negative correlation was found with NO (r = -0.5534,P < 0.0001).LINC01123 (OR: 2.141, 95%CI: 1.339 -3.424, P = 0.001) was identified as an independent risk factor of hypertension.LINC01123 knockdown contributed to improving the proliferation and migration of HUVECs while inhibiting its apoptosis.MiR-34a-5p was a potential target of LINC01123.The significantly elevated LINC01123 was positively associated with blood pressure and vascular dysfunction in hypertension.LINC01123 was an independent risk factor for hypertension.LINC01123 knockdown facilitated the cell proliferation and migration while inhibiting apoptosis of HUVECs maybe via miR-34a-5p.