MiR-126-3p Inhibits the Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Targeting SLC7A5

Polycystic ovary syndrome (PCOS) affects the health of many females of childbearing age.PCOS cannot be completely cured at present, so it is very important to study the pathogenesis.MiR-126-3p expression was detected by RT-qPCR.The receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic value.In KGN cells, miR-126-3p and solute carrier family 7 member 5 (SLC7A5) were overexpressed or inhibited by transfection.The target of miR-126-3p was forecasted using the miRDB database.The correlation of the two in PCOS was proved using Pearson correlation analysis.MiR-126-3p and SLC7A5 were knocked down in KGN cells to detect the function of both in PCOS.MiR-126-3p was reduced and had a high diagnostic value in PCOS.In KGN cells, overexpressed miR-126-3p increased the proliferation and decreased the apoptosis, while inhibited miR-126-3p decreased the proliferation and increased the apoptosis.SLC7A5 in PCOS was increased and was negatively regulated by miR-126-3p.In KGN cells, the simultaneous overexpression of SLC7A5 and miR-126-3p decreased the proliferation and increased the apoptosis compared with the overexpression of miR-126-3p.MiR-126-3p decreased and had a diagnostic value in PCOS.In KGN cells, SLC7A5 was the target gene of miR-126-3p, with which it exhibited a negative correlation.