Association between <i>P2RX7</i> rs7958311 Polymorphism and Labor Analgesia in Primiparas

Labor analgesia is commonly used in parturient women and its variable effect has been proven to be related to genetic factors.The P2RX7 rs7958311 polymorphism is closely associated with the occurrence and sensitivity of pain.This study focused on the correlation between the P2RX7 rs7958311 polymorphism and labor analgesia in primiparas.Two hundred full-term hospitalized primiparas who voluntarily requested labor analgesia were recruited in this study.P2RX7 rs7958311 genotyping was performed on all participants after genomic DNA extraction from blood samples.Ropivacaine combined with sufentanil was employed for labor analgesia.Evaluation was performed on pain scores, labor duration, and maternal and infant outcomes.Potential factors affected by rs7958311 polymorphism were assessed by logistic regression analysis.Obviously, reduced VAS scores were shown within 1h after labor analgesia and at 2 h postpartum in in GA and AA groups (P<0.05) with lower VAS scores in the AA group than in the GA group (P<0.01) at 2 h postpartum.The total and the first two stages of labor exhibited a shortened duration in the AA group (P<0.05).Analysis of adverse reactions in primiparas and assessment of neonates identified a statistical difference in nausea/emesis (P=0.005)among 3 groups.Logistic regression analysis demonstrated the effect of P2RX7 rs7958311 polymorphism on the VAS score at 2 h postpartum (OR=0.386,95% CI: 0.192-0.777,P=0.008) and nausea/emesis (OR=0.232,95% CI: 0.071-0.762,P=0.016) in primiparas.The P2RX7 rs7958311 polymorphism remarkably influenced the effect of labor analgesia in primiparas, especially the VAS score at 2 h postpartum and nausea/emesis.