Analyzing real-world adverse events of spironolactone with the FAERS database

While most findings were consistent with spironolactone's known effects, new signals, including a potential link to male endometriosis in high-risk groups, were identified. Further research is needed to confirm these findings and improve long-term safety assessment and clinical management.

Authors

Cheng Wen (ORCID: https://orcid.org/0000-0002-7179-8430)
Xiaowei Yan (ORCID: https://orcid.org/0000-0002-4846-8812)
Zigang Li (ORCID: https://orcid.org/0000-0002-6668-5589)
Lixian Li (ORCID: https://orcid.org/0000-0003-4353-2229)
Ru Chen (ORCID: https://orcid.org/0009-0007-1937-2188)
Guo‐Qiang Lin

Institutions

Fujian Medical University (CN)
Union Hospital (CN)
Putian University (CN)

Publication Details

Journal: PLoS ONE
Published: 2025-09-17
DOI: https://doi.org/10.1371/journal.pone.0330659
Citations: 1
Primary Topic: Pharmacovigilance and Adverse Drug Reactions
Type: article
Field-Weighted Citation Impact: 1.31

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article

Analyzing real-world adverse events of spironolactone with the FAERS database

Cheng Wen, Xiaowei Yan, Zigang Li, Lixian Li et al.

Sep 17, 2025

1 citations

PLoS ONE

Pharmacovigilance and Adverse Drug Reactions

1.31

article

Analyzing real-world adverse events of spironolactone with the FAERS database

Cheng Wen, Xiaowei Yan, Zigang Li, Lixian Li, Ru Chen, Guo‐Qiang Lin

September 17, 2025article en

1 citations

Abstract

While most findings were consistent with spironolactone's known effects, new signals, including a potential link to male endometriosis in high-risk groups, were identified. Further research is needed to confirm these findings and improve long-term safety assessment and clinical management.

PLoS ONEVol. 20(9)

Fujian Medical University (CN), Union Hospital (CN), Putian University (CN)

Openalex Percentile: Top 19%

Pharmacovigilance and Adverse Drug Reactions

1.31

DOI Open Access PDF OpenAlex

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