Progesterone induction of tau phosphorylation during the differentiation of human embryonic stem cells into neuroectodermal rosettes
These preliminary results suggest that progesterone induces tau expression and its phosphorylation during the differentiation of neuroectodermal rosettes from hESC and suggest that tau and its phosphorylation is obligatory for neuronal precursor cell mitosis. The parallels between neural embryogenesis and neurodegeneration are discussed in the context of tau phosphorylation and the aberrant re-entry of neurons into the cell cycle in AD.
Authors
- Sivan Vadakkadath Meethal
- Prashob Porayette (ORCID: https://orcid.org/0000-0001-9078-5128)
- Tracy Butler (ORCID: https://orcid.org/0000-0003-0130-8122)
- Maria M. Kaltcheva
- Craig Atwood (ORCID: https://orcid.org/0000-0001-5040-1679)
- George Perry (ORCID: https://orcid.org/0000-0002-6547-0172)
Institutions
- Edith Cowan University (AU)
- University of Wisconsin–Madison (US)
- Cornell University (US)
- MIND Research Institute (US)
- Geriatric Research Education and Clinical Center (US)
- Weill Cornell Medicine (US)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/25424823251370643
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00