Increasing alignment of large language models with language processing in the human brain

Transformer-based large language models (LLMs) have considerably advanced our understanding of how meaning is represented in the human brain; however, the validity of increasingly large LLMs is being questioned due to their extensive training data and their ability to access context thousands of words long. In this study we investigated whether instruction tuning-another core technique in recent LLMs that goes beyond mere scaling-can enhance models' ability to capture linguistic information in the human brain. We compared base and instruction-tuned LLMs of varying sizes against human behavioral and brain activity measured with eye-tracking and functional magnetic resonance imaging during naturalistic reading. We show that simply making LLMs larger leads to a closer match with the human brain than fine-tuning them with instructions. These finding have substantial implications for understanding the cognitive plausibility of LLMs and their role in studying naturalistic language comprehension.

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Publication Details

Journal
Nature Computational Science
Published
2025-09-16
DOI
https://doi.org/10.1038/s43588-025-00863-0
Citations
5
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
12.40

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article

Increasing alignment of large language models with language processing in the human brain

Jixing Li, Jiajun Chen, Ping Li, Changjiang Gao et al.
5 citations
Nature Computational Science
Topic Modeling
12.40
article

Increasing alignment of large language models with language processing in the human brain

Jixing Li, Jiajun Chen, Ping Li, Changjiang Gao, Shujian Huang, Z. Ma
article en
5 citations

Abstract

Transformer-based large language models (LLMs) have considerably advanced our understanding of how meaning is represented in the human brain; however, the validity of increasingly large LLMs is being questioned due to their extensive training data and their ability to access context thousands of words long. In this study we investigated whether instruction tuning-another core technique in recent LLMs that goes beyond mere scaling-can enhance models' ability to capture linguistic information in the human brain. We compared base and instruction-tuned LLMs of varying sizes against human behavioral and brain activity measured with eye-tracking and functional magnetic resonance imaging during naturalistic reading. We show that simply making LLMs larger leads to a closer match with the human brain than fine-tuning them with instructions. These finding have substantial implications for understanding the cognitive plausibility of LLMs and their role in studying naturalistic language comprehension.

Nature Computational ScienceVol. 5(11)
Hong Kong Polytechnic University (HK), City University of Hong Kong (HK), Nanjing University of Science and Technology (CN)
National Science Foundation, City University of Hong Kong
Openalex Percentile: Top 2%
Topic Modeling
12.40
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Increasing alignment of large language models with language processing in the human brain — Jixing Li, Jiajun Chen, et al. · Nature Computational Science (2025) | TGRS Research Map | TGRS