Mechanism and Clinical Study of Ergothioneine from Golden Oyster Mushroom on Anti - Aging Effects of Human Skin and Cells

Aging is a natural phenomenon in the process of life, which is not only a research focus of modern medicine, but also a long-term topic of exploration in cell biology. Cell biology believes that aging is a process of cellular function degradation over time, which is influenced by multiple factors and mainly involves the following core mechanisms: cell apoptosis and failure, decreased mitochondrial function, shortened cell telomeres, and chronic low-grade inflammation. These mechanisms interweave with each other, gradually leading to "aging manifestations" such as skin laxity, cognitive decline, and metabolic decline.Golden Oyster Mushroom (Pleurotus citrinopileatus Sing.), as a natural fungus with both medicinal and edible values, its active ingredient ergothioneine has been confirmed by modern research to have significant antioxidant, anti - glycation and skin aging - delaying effects. Based on the theory of "human aging originates from cell aging" in cell biology, combined with the 28 - day randomized double - blind clinical trial data of GOM - HCEr® ergothioneine from Golden Oyster Mushroom, this study systematically explores its anti - aging effect. The test results show that continuous daily intake of 100mg GOM - HCEr® can effectively improve the skin gloss (increased by 3.638%), elasticity (increased by 5.357%), water content (increased by 7.599%) and reduce the wrinkle area (decreased by 21.071%) of the subjects, and show significant advantages over the placebo group in anti - glycation reaction. Based on the theory of cell biology research, this experimental study believes that ergothioneine contained in GOM-HCEr® can delay skin aging through cell biological processes such as mitochondrial function protection, DNA repair, inflammatory aging regulation, and Sirtuin pathway activation.