Oxidation of dihydrotetrazine triggered by near-infrared photocatalysis for photoclick chemistry
Using biocompatible near-infrared light to trigger click reactions offers a powerful approach for achieving spatiotemporal control in bioconjugate chemistry. This study demonstrates an 810-nm-wavelength photooxidation of dihydrotetrazine using cyanine as a photocatalyst to unlock the tetrazine function. This activation enables the inverse electron-demand Diels-Alder reaction with strained alkenes.
Authors
- Morgan Cormier (ORCID: https://orcid.org/0000-0002-2469-3345)
- Michael J. Walter (ORCID: https://orcid.org/0000-0002-1703-9994)
- Mary‐Lorène Goddard
- Jean‐Philippe Goddard (ORCID: https://orcid.org/0000-0001-7265-7587)
- Murat Cihan (ORCID: https://orcid.org/0009-0005-8632-9089)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Haute-Alsace (FR)
- Laboratoire d'innovation moléculaire et applications (FR)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03860j
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00