Labeling configuration optimization of Pseudo-Continuous Arterial Spin Labeling in the intraoperative setting at 3 Tesla.

Motivation: Improve the image quality of the PCASL intraoperative images for resection control in brain tumor surgery at 3T. Goal(s): Optimize the PCASL labeling parameters to make the sequence robust in the intraoperative setting, evaluating the effect of shortening the RF spacing and increasing the Gave on the labeling efficiency in brain tumors intraoperative patients. Approach: Two experiments were performed during intraoperative MRI to evaluate the effect on the labeling efficiency of: shortening the RF spacing and increasing Gave. Results: For the second experiment the CBF values obtained are higher for the PCASL labeling configuration optimized. Impact: A PCASL labeling configuration robust to off-resonance effects and to low blood velocities was obtained by shortening RF spacing and increasing the Gave .The labeling configuration proposed could be beneficial in situations with similar circumstances.