Blood-brain barrier water permeability in relation to Alzheimer’s Disease and age-related vascular damage
Motivation: Blood-brain barrier (BBB) permeability changes may be implicated in both Alzheimer's Disease (AD) and cerebrovascular aging. Goal(s): To investigate if the exchange time (Tex) of blood water across the BBB is associated with AD and vascular parameters. Approach: We measured Tex with a multi-echo arterial spin labeling MRI sequence in 137 adults older than 50 years and studied its association with cognitive stage, amyloid status, and vascular parameters (blood pressure and FLAIR white matter hyperintensities). Results: BBB Tex was lower in MCI patients than in healthy controls. Tex was also lwoer in amyloid positive participants. Tex was not associated with the vascular parameters. Impact: Our results suggest that multi-TE ASL MRI BBB water permeability can be used as an early imaging biomarker of AD pathophysiology.
Authors
- Markus H. Sneve (ORCID: https://orcid.org/0000-0001-7644-7915)
- Lene Pålhaugen
- David Vállez García (ORCID: https://orcid.org/0000-0003-3308-3167)
- Anders M. Fjell (ORCID: https://orcid.org/0000-0003-2502-8774)
- Klaus Eickel (ORCID: https://orcid.org/0000-0002-5700-2029)
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- Oliver Marcel Geier (ORCID: https://orcid.org/0000-0003-3919-7579)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Sandra Tecelão
- Amnah Mahroo (ORCID: https://orcid.org/0009-0005-8480-0965)
- Kristine B. Walhovd (ORCID: https://orcid.org/0000-0003-1918-1123)
- Atle Bjørnerud (ORCID: https://orcid.org/0000-0002-3486-3141)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Beatriz Padrela (ORCID: https://orcid.org/0000-0001-6836-9443)
- Per Selnes (ORCID: https://orcid.org/0000-0001-5131-9757)
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
- D. G. T. Thomas
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2994
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00