Biological impact of chemotherapy during treatment with EGFR tyrosine kinase inhibitors for non-small cell lung cancer positive for EGFR activating mutations
Chemotherapy has the potential to suppress the development of EGFR-TKI resistance as well as to inhibit tumor growth for NSCLC positive for EGFR activating mutations. Our results provide biological insight into combination treatment with EGFR-TKIs and chemotherapy for such patients.
Authors
- Ryo Toyozawa (ORCID: https://orcid.org/0009-0002-7688-5725)
- Shintaro Kanda (ORCID: https://orcid.org/0000-0001-7864-3928)
- Kazuto Nishio (ORCID: https://orcid.org/0000-0002-8275-0846)
- Gen Kida
- Kazuko Sakai (ORCID: https://orcid.org/0000-0003-1822-2720)
- Yasuhiko Nishioka (ORCID: https://orcid.org/0000-0001-6311-1654)
- Toshihide Yokoyama (ORCID: https://orcid.org/0000-0002-5595-5010)
- Nobuyuki Yamamoto (ORCID: https://orcid.org/0000-0002-7342-0853)
- Hirokazu Taniguchi (ORCID: https://orcid.org/0000-0003-2414-8344)
- Hiroshi Yokouchi (ORCID: https://orcid.org/0000-0001-5964-0051)
- Isamu Okamoto (ORCID: https://orcid.org/0000-0002-7587-6096)
- Yoshitaka Zenke (ORCID: https://orcid.org/0000-0002-7641-9065)
- K. Koyama
- Shunichi Sugawara (ORCID: https://orcid.org/0000-0002-3427-4558)
- Masayuki Hirose (ORCID: https://orcid.org/0000-0002-9115-0885)
- Eiji Iwama
- Yuichiro Ohe (ORCID: https://orcid.org/0000-0002-6137-073X)
- Taishi Harada (ORCID: https://orcid.org/0000-0002-5145-9036)
- Kaoru Tanaka (ORCID: https://orcid.org/0000-0002-4927-1368)
Institutions
- Kyushu University (JP)
- Wakayama Medical University (JP)
- Kurashiki Central Hospital (JP)
- Niigata Cancer Center Hospital (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Kyushu University Hospital (JP)
- Kyushu Hospital (JP)
- Saitama Cancer Center (JP)
- Shinshu University Hospital (JP)
- National Cancer Center Hospital East (JP)
- Sendai Kousei Hospital (JP)
- Nagasaki University (JP)
- Kindai University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Lung Cancer
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.lungcan.2025.108756
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04