Structured light radial-view endoscope PROBE for IMAGING of colorectal tissue

White-light endoscopy (WLE) is the current gold standard for endoscopic colorectal cancer screening. However, it lacks the ability to image subsurface colorectal tissue and provide functional assessments necessary for early-stage cancer identification and post-treatment evaluation. Spatial frequency domain imaging (SFDI) provides subsurface quantitative absorption and scattering properties, which can assist in distinguishing between different tissue types. In this paper, we present a new, to the best of our knowledge, compact, radial-view, dual-wavelength (740 nm and 850 nm) SFDI system and its accompanying reconstruction algorithm. The proposed system achieves real-time full circumferential imaging of the intestinal lumen and provides functional parameter estimation from a single snapshot. The performance of this endoscopic probe is evaluated using biomimetic microvascular phantoms, and its potential for biological tissue imaging is demonstrated through imaging of <i>ex vivo</i> human colorectal tissue.