Association between liver enzyme levels and prevalence of migraine: the atherosclerosis risk in communities study
Our findings suggest that higher AST, ALT, and GGT levels are associated with a lower prevalence of migraine. Although the exact mechanisms linking lower blood levels of AST, ALT, and GGT to migraines remain unclear, their association may be explained by inefficient plasma glutamate regulation, which could play a role in migraine pathology. This finding is important for patients as it sheds light on potential metabolic contributions to migraines, supporting the hypothesis that factors beyond traditional neurovascular theories are involved.
Authors
- Menglu Liang (ORCID: https://orcid.org/0000-0002-0185-8557)
- Elizabeth Selvin (ORCID: https://orcid.org/0000-0001-6923-7151)
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- Mariana Lazo (ORCID: https://orcid.org/0000-0002-3178-6734)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Angela Ruban (ORCID: https://orcid.org/0000-0003-1091-8854)
- Andrea Schneider (ORCID: https://orcid.org/0000-0002-4674-7244)
- Silvia Koton (ORCID: https://orcid.org/0000-0002-9327-7505)
Institutions
- Johns Hopkins University (US)
- Tel Aviv University (IL)
- National Institute of Neurological Disorders and Stroke (US)
- Drexel University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Therapeutic Advances in Neurological Disorders
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/17562864251370097
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16