A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice

Although the prevalence of aortic regurgitation (AR), which causes eccentric remodeling and valvular heart disease (VHD), is increasing, suitable animal research models remain lacking. To address this issue, we established the first efficient, real-time visualized minimally invasive aortic regurgitation surgery mouse model by performing echocardiography-guided aortic valve tear using a modified insulin needle. The clinically relevant features of this AR model were verified by multimodal analysis, and feature genes closely associated with AR-induced VHD were obtained by time series analysis in conjunction with weighted gene co-expression network analysis. The results may provide comprehensive insights into the mechanistic study and potential therapeutic targets of AR-induced VHD.

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Publication Details

Journal
JACC Basic to Translational Science
Published
2025-09-17
DOI
https://doi.org/10.1016/j.jacbts.2025.101324
Citations
1
Primary Topic
Cardiac Valve Diseases and Treatments
Type
article
Field-Weighted Citation Impact
1.39
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article

A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice

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1 citations
JACC Basic to Translational Science
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1.39
article

A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in Mice

Honghua Chen, Weijiang Tan, Jianguo Jia, Jian Wu, Le Kang, Shuang Zheng, Hui Gong, Fenghua Yang, Xuecong Ren, Xuan Li, Kuan Cheng, Shijun Wang, Xiang Li, Huan Sun, Chunjie Yang, Yunzeng Zou
article en
1 citations

Abstract

Although the prevalence of aortic regurgitation (AR), which causes eccentric remodeling and valvular heart disease (VHD), is increasing, suitable animal research models remain lacking. To address this issue, we established the first efficient, real-time visualized minimally invasive aortic regurgitation surgery mouse model by performing echocardiography-guided aortic valve tear using a modified insulin needle. The clinically relevant features of this AR model were verified by multimodal analysis, and feature genes closely associated with AR-induced VHD were obtained by time series analysis in conjunction with weighted gene co-expression network analysis. The results may provide comprehensive insights into the mechanistic study and potential therapeutic targets of AR-induced VHD.

JACC Basic to Translational ScienceVol. 10(10)
Sun Yat-sen University (CN), Fudan University (CN), Zhongshan Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Guangdong Laboratory Animals Monitoring Institute (CN), Union Hospital (CN)
Openalex Percentile: Top 15%
Cardiac Valve Diseases and Treatments
1.39
DOIOpen Access PDFOpenAlex
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