Germinomas: Nestin and CD15 Expression in Tumor Blood Vessels
Germinomas constitute two-thirds of intracranial germ cell neoplasms, with a woman: male ratio of 8:22. A characteristic of this tumor is its adequate vascularity, which has not been previously studied with markers such as Nestin, YAP and CD15, and which can provide valuable information about the biology of this tumor. These markers were analyzed by immunohistochemistry, showing tumor blood vessels cytoplasmic staining for nestin and for CD15, demonstrating angiogenesis as an important mechanism in germinomas.
Authors
- Ana Laura Calderón‐Garcidueñas (ORCID: https://orcid.org/0000-0002-2652-3825)
- Carlos Eduardo Diéguez-Campa (ORCID: https://orcid.org/0000-0002-4534-5921)
- Carlos Alcalá‐Romero (ORCID: https://orcid.org/0000-0001-7913-0542)
- Sanjuana Berenice Treviño‐Solís
Institutions
- Instituto Nacional de Neurología y Neurocirugía (MX)
Publication Details
- Journal
- Pathology International
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1111/pin.70050
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00