ATG16L strikes again! New findings link lysosome stress and physiology
Lysosome stress responses are emerging, but their connections to normal physiology are not well understood. In this issue, Duque et al. (https://doi.org/10.1083/jcb.202503166) discover that the autophagy protein ATG16L, a mediator of a stress response called CASM, also regulates normal lysosome function.
Authors
- Alison D. Klein (ORCID: https://orcid.org/0009-0008-3819-8610)
- Michael Overholtzer (ORCID: https://orcid.org/0000-0003-3007-4986)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1083/jcb.202509030
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00