Trolox, r-irisin and resveratrol cocktail to counteract osteoblast metabolism alterations in osteoarthritis and osteoporosis
The improvement in cell viability and reduction in oxidative stress and cellular senescence observed through treatment-induced modulation of the NOX4-SIRT1 axis and PTX3 suggests a protective role for these biomarkers in bone metabolism. These findings could offer new perspectives in counteracting the effects of aging on the skeletal system by improving bone health and mitigating metabolic alterations.
Authors
- Giovanna D’Arcangelo (ORCID: https://orcid.org/0000-0002-2105-0395)
- Angela Falvino
- Roberto Bonanni (ORCID: https://orcid.org/0000-0002-7174-0714)
- Ida Cariati (ORCID: https://orcid.org/0000-0002-2102-5034)
- Virginia Tancredi (ORCID: https://orcid.org/0000-0003-4779-2212)
- Anna Maria Rinaldi (ORCID: https://orcid.org/0000-0003-4106-8127)
- Lucia Tranquillo
- Umberto Tarantino (ORCID: https://orcid.org/0000-0003-0330-2189)
- Amarildo Smakaj (ORCID: https://orcid.org/0000-0002-7566-6785)
- Pierangelo Cifelli
Institutions
- University of Rome Tor Vergata (IT)
- University of L'Aquila (IT)
- Catholic University Our Lady of Good Counsel (AL)
- Policlinico Tor Vergata (IT)
Publication Details
- Journal
- Journal of Bone and Mineral Metabolism
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1007/s00774-025-01642-7
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16