Frailty and Effects of Semaglutide in Obesity-Related HFpEF
Semaglutide resulted in a similar reduction in BW across frailty subgroups but greater improvements in HF-related symptoms. Moreover, semaglutide reduced frailty burden after 52 weeks of treatment. (Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity [STEP-HFpEF]; NCT04788511) (Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes [STEP-HFpEF DM]; NCT04916470).
Authors
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- A. Domdey (ORCID: https://orcid.org/0000-0002-2942-5956)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Ambarish Pandey (ORCID: https://orcid.org/0000-0001-9651-3836)
- Michael Fu (ORCID: https://orcid.org/0000-0001-8860-1051)
- Morten Schou (ORCID: https://orcid.org/0000-0002-4271-2466)
- Khaja Chinnakondepalli (ORCID: https://orcid.org/0000-0002-7405-8614)
- Mikhail Kosiborod (ORCID: https://orcid.org/0000-0002-3750-9789)
- Cecilia Rönnbäck
- Fozia Ahmed (ORCID: https://orcid.org/0000-0001-9769-0180)
- Eduardo Perna (ORCID: https://orcid.org/0000-0002-9977-7623)
- Subodh Verma (ORCID: https://orcid.org/0000-0002-4018-8533)
- Melanie Jane Davies (ORCID: https://orcid.org/0000-0002-9987-9371)
- Karoline Liisberg
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Dalane W Kitzman
- Shachi Patel
- Barry A Borlaug
Institutions
- Northwestern University (US)
- University of Copenhagen (DK)
- St. Michael's Hospital (CA)
- Mayo Clinic (US)
- University of Toronto (CA)
- Novo Nordisk (Denmark) (DK)
- Sahlgrenska University Hospital (SE)
- Gentofte Hospital (DK)
- Baylor Medical Center at Garland (US)
- Saint Luke's Hospital (US)
- Research Institute of Dallas (US)
- NIHR Leicester Biomedical Research Centre (GB)
- Wake Forest University (US)
- Keele University (GB)
- University of Glasgow (GB)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.jchf.2025.102610
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- Novo Nordisk