Integrative Mutational Landscape of Mycosis Fungoides Using a National Genomics Repository
The findings of this study provide a comprehensive understanding of MF's molecular profile. The discovery of commonly mutated pathways (Wnt, p53, JAK/STAT, and epigenetic regulators) suggests potential targets for the development of future therapies. Furthermore, the enrichment of certain mutations based on race and patterns of alteration co-occurrence offer possibilities for patient-tailored treatment approaches.
Authors
- Peter T. Silberstein (ORCID: https://orcid.org/0000-0003-1207-0287)
- Abubakar Tauseef (ORCID: https://orcid.org/0000-0002-4317-1868)
- Beau Hsia (ORCID: https://orcid.org/0009-0009-6403-502X)
- Grace S. Saglimbeni (ORCID: https://orcid.org/0009-0006-1993-9554)
Institutions
- Creighton University (US)
- CHI Health Creighton University Medical Center - Bergan Mercy (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3390/cancers17182984
- Citations
- 2
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 4.01