Comparative Analysis of Oncotype DX Recurrence Scores in Screen‑Detected Versus Symptomatic Early‑Stage Breast Cancer: The COSSEB Study
Screen-detected and symptomatic ER-positive/HER2-negative early breast cancers exhibited broadly comparable ODX-RS distributions. Mode of presentation alone should therefore not dictate adjuvant chemotherapy decisions; multigene testing and standard clinicopathologic factors remain essential for individualized treatment planning. Larger, prospective studies are warranted to validate and extend these observations.
Authors
- Abdalla Saad Abdalla Al‐Zawi (ORCID: https://orcid.org/0000-0002-8576-3271)
- Najwa Abduljawad
- Zina Aladili
- Beata Adamczyk
- Piotr Nowaczyk (ORCID: https://orcid.org/0000-0002-6605-7646)
- Philip Idaewor (ORCID: https://orcid.org/0000-0002-5419-7465)
Institutions
- Basildon and Thurrock University Hospitals NHS Foundation Trust (GB)
- Southend University Hospital NHS Foundation Trust (GB)
- South Essex Partnership University Foundation NHS Trust (GB)
- Omar Al-Mukhtar University (LY)
- Greater Poland Cancer Center (PL)
- Basildon Hospital (GB)
- Anglia Ruskin University (GB)
Publication Details
- Journal
- Cureus
- Published
- 2025-09-12
- DOI
- https://doi.org/10.7759/cureus.92141
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00