Icaritin inhibits osteoclast differentiation and reduces bone loss by targeting ESR1 to inhibit miR503/RANK pathway
Taken together, our study confirmed that ESR1 is the direct target of ICT, and Asparagine at 455 is the direct binding site of ICT, and ICT inhibits OC differentiation and reduces bone loss by targeting ESR1 to upregulate miR503 level and weaken miR503/RANK pathway.
Authors
- Liuyan Xin
- Xiaofei Liao (ORCID: https://orcid.org/0000-0002-8860-9034)
- Zhen Xie (ORCID: https://orcid.org/0000-0002-7903-1162)
- Hongliang Li (ORCID: https://orcid.org/0000-0002-9821-0297)
- Jin‐Ping Li (ORCID: https://orcid.org/0000-0002-4255-3581)
- Baoping Xie (ORCID: https://orcid.org/0000-0001-8531-9798)
- Qi Jin (ORCID: https://orcid.org/0000-0002-9547-1192)
- An Li (ORCID: https://orcid.org/0000-0002-8476-8783)
Institutions
- Jiangnan University (CN)
- Central South University (CN)
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fphar.2025.1603333
- Citations
- 2
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 3.11