Function value of basement membrane-related genes in odontogenic keratocyst by bioinformatics analysis
This study establishes dysregulation f BMGs-particularly stromal fibroblast-specific SPARC overexpression-as a contributor to OKC pathogenesis. SPARC interacts with key OKC pathways (Hedgehog, NOTCH) and modulates the immune microenvironment. These findings provide foundational insights into OKC aggressiveness and propose SPARC as a potential therapeutic target.
Authors
- Zhengfei Zhu (ORCID: https://orcid.org/0000-0001-7537-3619)
- Jing‐Rui Yi
- Qi‐Wen Man (ORCID: https://orcid.org/0000-0001-8478-2086)
- Xuan-Hao Liu (ORCID: https://orcid.org/0009-0003-8993-9857)
- Nian‐Nian Zhong (ORCID: https://orcid.org/0000-0001-9226-4860)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0001-8702-5291)
- Bing Liu (ORCID: https://orcid.org/0000-0002-2024-6353)
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fonc.2025.1658125
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00