Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy
Plasma EVs contain protein biomarkers that can be used to monitor the response to treatment, some of which are detectable in whole plasma after 1 month of treatment. Our study also provides a proteomic landscape of plasma EVs involved in VL, offering insight into the pathogenesis of this complex disease.
Authors
- Eugenia Carrillo (ORCID: https://orcid.org/0000-0002-7869-7915)
- José Carlos Solana (ORCID: https://orcid.org/0000-0002-0485-6127)
- Javier Moreno (ORCID: https://orcid.org/0000-0003-0087-4659)
- Rodrigo Barderas (ORCID: https://orcid.org/0000-0003-3539-7469)
- Lorena Bernardo (ORCID: https://orcid.org/0000-0002-6899-4844)
- Juan San Martín (ORCID: https://orcid.org/0000-0003-4457-5124)
- Carmen Sánchez (ORCID: https://orcid.org/0000-0002-6663-7325)
- A. Torres (ORCID: https://orcid.org/0000-0001-5178-1917)
- Ana Montero-Calle
- Marina Lozano-Rendal
Institutions
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario de Fuenlabrada (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1646335
- Citations
- 1
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.88