Single-cell RNA profiling of colorectal granular-type laterally spreading tumor uncovers progression trajectory toward carcinoma and transcriptional signatures favoring lateral morphogenesis
The differentiation state of cells within LST-G exhibits a close correlation with their diverse characteristics. Metaplastic differentiation, as a prominent feature at the transcriptional level, demonstrates significant associations with the genomic features, morphogenesis, and tumor progression of LST-G.
Authors
- Yueqing Gong (ORCID: https://orcid.org/0000-0001-6741-0475)
- Jingjing Lu (ORCID: https://orcid.org/0000-0003-2841-3117)
- Fang Gu (ORCID: https://orcid.org/0000-0001-7833-0585)
- Xun Liu (ORCID: https://orcid.org/0000-0003-1366-8926)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-9224-6299)
- Jun Li (ORCID: https://orcid.org/0000-0002-7236-8088)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0004-6159-9309)
- Wei‐Wei Fu (ORCID: https://orcid.org/0000-0001-7681-7015)
- Rongli Cui
- Shigang Ding
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fonc.2025.1552841
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00