Analysis of brain necrosis and secondary cancers after proton beam therapy for pediatric intracranial tumors: a single-center retrospective study
This single-center retrospective study shows a low incidence of brain necrosis and secondary malignancy following PBT for pediatric patients with intracranial tumors. These findings indicate a favorable long-term safety profile of PBT in this population.
Authors
- Keiichiro Baba
- Masatoshi Nakamura (ORCID: https://orcid.org/0009-0008-3329-5999)
- Taisuke Sumiya (ORCID: https://orcid.org/0000-0001-5446-0705)
- Sho Hosaka (ORCID: https://orcid.org/0000-0002-2792-1235)
- Ai Muroi (ORCID: https://orcid.org/0000-0002-4983-6306)
- Masashi Mizumoto (ORCID: https://orcid.org/0000-0001-7837-1301)
- Masako Inaba
- Hiroko Fukushima (ORCID: https://orcid.org/0000-0002-1290-3501)
- Yuni Yamaki (ORCID: https://orcid.org/0000-0003-4287-5713)
- Toshitaka Ishiguro (ORCID: https://orcid.org/0000-0001-5018-4248)
- Kei Nakai (ORCID: https://orcid.org/0000-0002-0702-2304)
- Haruko Numajiri
- Hideyuki Sakurai (ORCID: https://orcid.org/0000-0002-0576-8639)
- Hikaru Niitsu (ORCID: https://orcid.org/0000-0001-8127-254X)
- Takashi Saito (ORCID: https://orcid.org/0000-0002-8253-7906)
- Yoshiko Oshiro
- Toshiki Ishida (ORCID: https://orcid.org/0009-0002-8158-9875)
- Masahiko Harada
Institutions
- University of Tsukuba (JP)
- University of Tsukuba Hospital (JP)
- Tsukuba Medical Center Hospital (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fonc.2025.1644839
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00