Virus-like particles containing the extracellular domain of G protein in combination with a CTL peptide of M2 elicit protection against respiratory syncytial virus infection without pulmonary disease
Our findings demonstrate that vaccination with G<sub>ECD</sub>/M2<sub>82-90</sub>-VLPs elicited a balanced immune response and conferred protection against RSV infection without immunopathology. These data demonstrate that the G<sub>ECD</sub>/M2<sub>82-90</sub>-VLPs are a potential RSV subunit vaccine candidate.
Authors
- Huan Qin (ORCID: https://orcid.org/0000-0002-2398-8758)
- Zishu Pan (ORCID: https://orcid.org/0000-0002-5326-3264)
- Jin Luo (ORCID: https://orcid.org/0000-0001-8410-0444)
Institutions
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Wuhan Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1625670
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00