Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults
Levels of some cytokines were generally more sustained in the Janssen group compared to the Pfizer group. Heterologous vaccine recipients exhibited more efficient cellular immune responses compared to homologous recipients. In addition, T-cell inhibitory molecule kinetics suggests an efficient T-cell activity. These findings may have implications for the overall induction of long-term protective immunity by the two vaccine types.
Authors
- Diana Ahu Prah (ORCID: https://orcid.org/0000-0002-8604-7525)
- Frank Osei (ORCID: https://orcid.org/0000-0003-2206-3662)
- Vincent Amarh (ORCID: https://orcid.org/0000-0002-6681-8118)
- Doreen Teye‐Adjei
- Selorm Philip Segbefia (ORCID: https://orcid.org/0000-0001-5795-8314)
- Jones A. Amponsah
- Godfred Futagbi
- Stella Nartey
- Abigail Naa Adjorkor Pobee
- Frederica Dedo Partey (ORCID: https://orcid.org/0000-0002-3977-1449)
- Dorcas Obiri‐Yeboah (ORCID: https://orcid.org/0000-0003-4562-9294)
- Michael F. Ofori (ORCID: https://orcid.org/0000-0003-2341-7514)
- Kwadwo Asamoah Kusi (ORCID: https://orcid.org/0000-0001-5483-9985)
- Theophilus Brenko (ORCID: https://orcid.org/0009-0000-8792-2777)
- Oscar Nii Otto Darko
- Kekeli Korshi Tudzi
- Isaac Otieno Othol
- Evans Nii Armah-Vedjesu
Institutions
- University of Cape Coast (GH)
- University of Ghana (GH)
- Noguchi Memorial Institute for Medical Research (GH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1643083
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00