IKZF1 exacerbates the inflammatory response by epigenetically modulating mitochondrial function following acute peritonitis
IKZF1 exacerbates macrophage inflammation in CLP-induced peritonitis by epigenetically silencing SDHB via HDAC3-mediated deacetylation, thereby disrupting mitochondrial metabolism and amplifying pro-inflammatory signals. Targeting IKZF1 or enhancing acetylation may represent novel therapeutic strategies for acute inflammatory conditions. This study establishes IKZF1 as a potential biomarker and therapeutic target for mitigating excessive inflammation in peritonitis.
Authors
- Pengfei Hu (ORCID: https://orcid.org/0000-0002-3326-2854)
- Yuantao Su (ORCID: https://orcid.org/0009-0001-4651-300X)
- G Liu
- Zhengyao Yang
- Ying Dong (ORCID: https://orcid.org/0000-0002-4397-4695)
- Yamin Xu (ORCID: https://orcid.org/0009-0001-1663-1953)
- Zihao Qi (ORCID: https://orcid.org/0000-0003-4791-4777)
Institutions
- Huadong Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1600903
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00