Early assessment and analysis of high-risk factors of neurodevelopmental impairment in neonates with congenital diaphragmatic hernia
LHR < 1.5, PPHN, and open surgery are independent predictors of neurodevelopmental impairment in CDH neonates. The combined use of aEEG, rSO₂, and NBNA significantly improves the efficiency of early neurodevelopmental impairment identification (AUC = 0.960), outperforming single indicators. Clinicians should prioritize monitoring pulmonary hypoplasia and perinatal complications while adopting multimodal neuromonitoring to optimize early intervention strategies.
Authors
- Boliang Bai (ORCID: https://orcid.org/0000-0002-5433-3076)
- Ronghui Yu
- Lang Jiang (ORCID: https://orcid.org/0000-0003-3624-1618)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0001-6333-3740)
- Wenqiang Sun (ORCID: https://orcid.org/0000-0002-3885-9254)
- Wendong Liu (ORCID: https://orcid.org/0000-0003-2804-5334)
- Xueping Zhu (ORCID: https://orcid.org/0000-0002-3502-7655)
- Guanghao Su
Institutions
- Soochow University (CN)
- Children's Hospital of Suzhou University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fped.2025.1632735
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00