Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment

During the eyes-open resting-state, differences of two groups in neural oscillations were primarily observed in the alpha and delta bands. The MCI exhibited significantly decreased alpha oscillations in the frontal lobe and increased delta oscillations in the frontal and parietal lobes. However, dynamic FC differences were most prominent in the delta and theta bands, including significantly increased interconnectivity of the prefrontal parietal network and significantly increased bottom-up FC. These findings emphasize the necessity of comprehensive analysis of local activity and large-scale network dynamics in MCI.