Identification and functional characterization of a novel Acinetobacter pittii bacteriophage-encoded depolymerase
These findings support the potential of 31TSP as an antibacterial agent against Acinetobacter infections. The observed synergy with conventional antibiotics, such as ampicillin, suggests a promising combinatorial strategy for future therapeutics targeting <i>Acinetobacter</i>. The enzyme's stability under extreme conditions of temperature and pH further underscores its therapeutic potential. However, its instability in varying ionic environments and lack of serum bactericidal enhancement highlight aspects requiring further investigation for clinical application.
Authors
- Santasree Banerjee (ORCID: https://orcid.org/0000-0003-2481-4562)
- Xu Jing (ORCID: https://orcid.org/0000-0001-6877-3577)
- Xue Du (ORCID: https://orcid.org/0000-0002-3765-6594)
- Muhammad Sheraz (ORCID: https://orcid.org/0000-0003-4780-6581)
- Zhan‐Qing Yang (ORCID: https://orcid.org/0000-0003-1416-7242)
- Hailin Jiang (ORCID: https://orcid.org/0009-0006-9220-700X)
- Wei Li (ORCID: https://orcid.org/0000-0001-6843-1980)
- Na Zhang (ORCID: https://orcid.org/0000-0003-4226-1586)
- Min Feng (ORCID: https://orcid.org/0000-0001-6262-911X)
- Hongyan Shi (ORCID: https://orcid.org/0000-0002-5089-0748)
- Honglan Huang
- Danish Daniyal
Institutions
- Jilin University (CN)
- Qujing Normal University (CN)
- Changchun University of Chinese Medicine (CN)
- Jilin Medical University (CN)
- First Bethune Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1608526
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43