Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pathway
YSHS inhibited podocyte apoptosis, protected the glomerular filtration barrier, attenuated proteinuria, and improved renal function indices by activating the GRP78/CHOP signaling pathway in the kidneys and the <i>in vitro</i> cultured podocytes of db/db mice.
Authors
- Kaidong Zhou
- Ge Jin (ORCID: https://orcid.org/0000-0002-8517-7969)
- Xin Zhou (ORCID: https://orcid.org/0000-0003-1076-1033)
- Min Zhang (ORCID: https://orcid.org/0000-0001-5812-9518)
- Xinxue Zhang (ORCID: https://orcid.org/0000-0001-9885-6402)
- Yanmo Cai
- Sitong Wang (ORCID: https://orcid.org/0000-0002-5448-8166)
- Yunhua Liu (ORCID: https://orcid.org/0000-0003-2017-3059)
- Zongjiang Zhao
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fphar.2025.1586333
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00