OvaRePred (HerTempo): an enhanced ovarian aging clock for personalized reserve assessment, endocrine age modeling, and predicting reproductive milestones across the female lifecycle

OvaRePred (HerTempo) delivers individualized, well-calibrated estimates of ovarian reserve and an interpretable endocrine-age index and future fertility milestone onset. While the tool can inform personalized fertility planning and may have broader public-health utility, the algorithm is trained on ART endpoints. Any projections of future reproductive milestones derived from the population ovarian-aging curve-and the fixed-interval hypothesis that underpins that curve-are hypothesis-generating and require prospective validation, particularly in non-ART cohorts with longitudinal follow-up.