The germinal center-tertiary lymphoid structure after neoadjuvant chemo-immunotherapy for locally advanced lung squamous cell carcinoma can predict the disease progression
This study reveals for the first time that NACT and NACT-IO enhance anti-tumor efficacy through multidimensional (abundance, spatial distribution and maturity) dynamic remodeling of TLS, and proposes the short course of ≤ 2 cycles of NACT-IO can maximize the prognostic value of GC-TLS, providing key evidence for optimizing the treatment ' time window '.
Authors
- Chan Yang (ORCID: https://orcid.org/0000-0002-5739-2549)
- Min Chen (ORCID: https://orcid.org/0000-0002-4443-7605)
- Yan Hong Huang (ORCID: https://orcid.org/0000-0001-5281-0783)
- Shuang Li (ORCID: https://orcid.org/0000-0002-9193-0320)
- Ping Zhou (ORCID: https://orcid.org/0009-0007-9923-9220)
- Lili Jiang (ORCID: https://orcid.org/0000-0002-8466-591X)
Institutions
- Shandong University of Aeronautics (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1579840
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05