Tracking prodromal Parkinson’s disease: a five-year follow-up of the PARCAS cohort
pPD probability showed high agreement between baseline and FU assessments. However, absence of key specific markers (PSG-confirmed iRBD and DaTscan) limited baseline sensitivity, which improved only near phenoconversion as additional prodromal symptoms accumulated. Identification of a prodromal CBS case illustrates the potential for detection of atypical parkinsonisms, even with non-α-synuclein pathology, suggesting limited specificity for PD.
Authors
- Norbert Leško (ORCID: https://orcid.org/0000-0002-0161-1685)
- Zuzana Gdovinová (ORCID: https://orcid.org/0000-0002-7396-5052)
- Kristína Kulcsárová (ORCID: https://orcid.org/0000-0003-3135-1826)
- Matěj Škorvánek (ORCID: https://orcid.org/0000-0001-5497-8715)
- Laura Gombošová
- Martina Bekeová (ORCID: https://orcid.org/0009-0005-2538-8894)
- Soňa Mrázová (ORCID: https://orcid.org/0009-0002-5320-7155)
- Soňa Muránska
- Petronela Christová
- Zuzana Mrazova
- Barbora Zecova
- Filip Faglic
- Simona Suvakova
Institutions
- University of Pavol Jozef Šafárik (SK)
- Univerzitná Nemocnica Louisa Pasteura (SK)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fneur.2025.1631165
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00