Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion
The computational model predicted reduction in global and regional contractility, and regional myocardial work done in the septum and LVFW with mechanical dyssynchrony are positively correlated with the corresponding decrease in experimentally measured regulated coronary flow in the LAD and LCX. These findings demonstrate that this interrelated mechanism between LV function and coronary flow in mechanical dyssynchrony may affect cardiac resynchronization therapy responder rate.
Authors
- Lei Fan
- Yousif Awakeem
- Farshad Raissi (ORCID: https://orcid.org/0000-0002-7663-4347)
- Jenny Susana Choy (ORCID: https://orcid.org/0000-0002-7032-0777)
- Lik Chuan Lee (ORCID: https://orcid.org/0000-0002-1123-6428)
- Ghassan S. Kassab (ORCID: https://orcid.org/0000-0001-7126-1484)
- Chenghan Cai
Institutions
- University of California San Diego (US)
- California Medical Innovations Institute (US)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3389/fbioe.2025.1630854
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00