CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF METABOLITES OF MELILOTUS OFFICINALIS

The review summarizes the data from scientific literature on the chemical composition, level of study, and biological activity of metabolites and extracts of Melilotus officinalis (L.) Pall. (common sweet clover). In folk medicine, common sweet clover is used for angina, coronary thrombosis, thrombophlebitis, and for the prevention of heart attacks and ischemic strokes. The wide spectrum of pharmacological activity of M. officinalis is due to the content of a complex of biologically active substances. Analysis of literature data on the chemical composition of M. officinalis metabolites indicates its diversity. The article presents information on the composition of the metabolites of sweet clover, related to terpenoids, coumarins, hydroxybenzoic acids, derivatives of cinnamic and dihydrocinnamic acids, flavonoids and isoflavonoids, lipids, carbohydrates, carotenoids, triterpenoids, saponins, phytosterols, amino acids, vitamins, carboxylic acids and other classes of natural biologically active compounds. The results of the study of the pharmacological activity of the extraction preparations and some individual compounds of M. officinalis show the prospects for their further study in a number of areas, as well as their use for the creation of drugs and parapharmaceutical products on their basis. The goal and objective of this article is to summarize and systematize numerous literary data on secondary metabolites and biological activity of extracts and individual compounds isolated from M. officinalis. The information provided in the review can be used as reference literature by phytochemists, biologists and pharmacologists.e review can be used as reference literature by phytochemists, biologists and pharmacologists.