A revolução silenciosa da pele: Biotecnologia do microbioma na vanguarda da cosmética e dermatologia

This integrative review article explores the paradigmatic shift in cosmetology and dermatology driven by advances in skin microbiome biotechnology. The objective is to critically analyze the role of the microbiome in skin homeostasis, the implications of dysbiosis in dermatopathies such as acne and atopic dermatitis, and emerging biotechnological strategies for its modulation. The methodology followed the Whittemore and Knafl framework, with a systematic search across five databases, resulting in 78 publications analyzed. Probiotic, prebiotic, and postbiotic approaches are detailed, synthesizing clinical evidence from recent meta-analyses including 127,150 participants. The analysis also addresses technological challenges in formulation, including microencapsulation systems and the application of artificial intelligence for personalization. The global market, valued at USD 1.03 billion in 2024 and projected to reach USD 2.86 billion by 2032 (CAGR 13.68%), underscores its commercial relevance. Future perspectives include engineered live biotherapeutics, modulation of the skin–brain–gut axis, and AI-based diagnostics, consolidating microbiome biotechnology as a central pillar for the future of skincare..