Untargeted metabolomic profiling in acute ischemic stroke patients with cerebral microbleeds

This study identified unique metabolic signatures in AIS patients with CMBs. The metabolites such as N-ethylglycine, aspartyl-glutamate, and oleamide were significantly elevated, while metabolites like PC (16:0/18:1) and PC (18:0/20:4) were significantly reduced, and other metabolites implicated disruptions in energy and lipid metabolism. These findings suggest potential biomarker candidates for diagnosis, prognosis, and therapeutic intervention in this high-risk population.