Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease
Our findings highlight the significant impact of early-life microbiota on the host metabolome and show that our two-generation HMA model is suitable for studying microbiota‒metabolome relationships relevant to humans. The differences in microbiota‒metabolome correlations between individuals who develop or do not develop allergic disease suggest that an allergic predisposition might be more multifaceted than previously believed.
Authors
- Klas I. Udekwu (ORCID: https://orcid.org/0000-0002-8434-0744)
- Isabella Badolati (ORCID: https://orcid.org/0000-0001-6619-6884)
- Douglas L. Huseby (ORCID: https://orcid.org/0000-0001-9974-578X)
- Omneya Ahmed Osman (ORCID: https://orcid.org/0000-0002-1289-5070)
- Claudia Moeckel
- Éva Hell
- Khaleda Rahman Qazi (ORCID: https://orcid.org/0000-0002-4892-7978)
- Dagbjort H. Petursdottír (ORCID: https://orcid.org/0000-0003-0665-7719)
- Diarmaid Hughes (ORCID: https://orcid.org/0000-0002-7456-9182)
- Sarahi L. Garcia (ORCID: https://orcid.org/0000-0002-8622-0308)
- Craig E. Wheelock (ORCID: https://orcid.org/0000-0002-8113-0653)
- António Checa (ORCID: https://orcid.org/0000-0001-7873-7545)
- Eva Sverremark‐Ekström (ORCID: https://orcid.org/0000-0001-6271-8681)
- Rana Melisa Seren
- Ymke A. de Jong
- Vida Ramšak Marčeta
Institutions
- Uppsala University (SE)
- Carl von Ossietzky Universität Oldenburg (DE)
- Karolinska University Hospital (SE)
- University of Idaho (US)
- Stockholm University (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1186/s12866-025-04321-9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00