Early astrocyte-targeted intervention guided by 18F-SMBT-1 imaging attenuates disease progression in 3xTg-AD mice
<sup>18</sup>F-SMBT-1 PET imaging served as a diagnostic biomarker for monitoring astrocyte reactivity to guide therapeutic timing decisions, and as a therapeutic response indicator for evaluating treatment efficacy. Early astrocyte-targeted intervention demonstrated significant therapeutic potential. These findings highlighted the translational potential of molecular imaging-guided strategies and astrocyte-targeted therapies in AD.
Authors
- Xianyi Cao (ORCID: https://orcid.org/0000-0003-2965-609X)
- Yuchun Chang (ORCID: https://orcid.org/0009-0002-8264-0230)
- Qi Huang (ORCID: https://orcid.org/0000-0001-6788-3432)
- Chenglai Fu (ORCID: https://orcid.org/0000-0003-4300-9948)
- Shenrui Guo
- Zhi‐Yin Lou
- Yafu Yin (ORCID: https://orcid.org/0000-0002-4818-6655)
- Sheng Liang (ORCID: https://orcid.org/0009-0008-8460-1749)
- Wei Feng (ORCID: https://orcid.org/0000-0001-7913-2011)
- Weiwei Cheng (ORCID: https://orcid.org/0000-0002-4907-7872)
- Yufei Ma
- Shuqi Wu
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1007/s00259-025-07559-7
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Ruijin Hospital