Long-term lymphedema and quality of life following lymph node staging in early cervical cancer: 3-year follow-up in the prospective multicenter SENTIREC CERVIX study
Patients with cervical cancer reported long-term leg lymphedema, most pronounced after sentinel lymph node mapping with pelvic lymphadenectomy, and to a lesser extent after sentinel lymph node mapping alone. Three-month leg lymphedema score predicted persistent lymphedema, which was significantly associated with deterioration in several quality of life symptoms and functioning. Our findings support less invasive surgical approaches and may inform shared decision-making and survivorship intervention.
Authors
- Pernille Tine Jensen (ORCID: https://orcid.org/0000-0002-1637-6040)
- Katrine Fuglsang (ORCID: https://orcid.org/0000-0002-2040-1173)
- Algirdas Markauskas (ORCID: https://orcid.org/0000-0002-4145-9120)
- Sara Elizabeth Sponholtz (ORCID: https://orcid.org/0000-0002-0679-2702)
- Ligita Paskeviciute Frøding (ORCID: https://orcid.org/0000-0001-7149-099X)
- Sarah Marie Bjørnholt (ORCID: https://orcid.org/0000-0001-9654-7876)
- Eva Bjerre Ostenfeld (ORCID: https://orcid.org/0000-0003-4125-4317)
- Erik Thorlund Parner (ORCID: https://orcid.org/0000-0003-3661-1922)
Institutions
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- American Journal of Obstetrics and Gynecology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.ajog.2025.09.020
- Citations
- 2
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.09