The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021
KS continues to represent a largely undetected pediatric health burden, especially in low- and middle-SDI settings. The findings highlight the urgent need for enhanced awareness, early detection strategies, and equitable access to genetic services in global child health policy. Timely diagnosis and intervention can help prevent long-term developmental and health-related consequences of KS.
Authors
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Jia Fan (ORCID: https://orcid.org/0000-0003-3487-2328)
- Guoqian Ma (ORCID: https://orcid.org/0009-0000-3203-4262)
Institutions
- Kunming Medical University (CN)
- Yunnan Maternal and Child Health (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fgene.2025.1639699
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00