Identification of amino acid metabolism-related gene Leucyl-tRNA synthetase 1 (LARS1) as a potential prognostic and therapeutic target in hepatocellular carcinoma
We have successfully developed a prognostic model based on 15 genes associated with amino acid metabolism. We also verified that knockdown of LARS1 significantly inhibited the proliferation, invasion and migration of HCC <i>in vitro</i>, with increased autophagy flux, indicating that LARS1 could be a potential therapeutic target for HCC.
Authors
- Qiyu Shi
- Jingwen Zhao (ORCID: https://orcid.org/0000-0001-8308-1384)
- Zhong‐Ren Peng (ORCID: https://orcid.org/0000-0003-3648-6770)
- Chao Li (ORCID: https://orcid.org/0000-0001-5723-1414)
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Yirong Chi
Institutions
- Tianjin Medical University General Hospital (CN)
- People's Hospital of Cangzhou (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fonc.2025.1675018
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00