HDAC inhibitor MS275 reprograms metabolism to induce differentiation and suppress proliferation in hepatocellular carcinoma
MS275 suppresses HCC cell proliferation and induces hepatocyte-like differentiation through PKM1-mediated metabolic reprogramming and ROS signaling. These findings support the potential of MS275 as a differentiation-based therapeutic strategy for HCC.
Authors
- Jiankai Liang (ORCID: https://orcid.org/0000-0002-4378-7646)
- Cheng Hu (ORCID: https://orcid.org/0000-0001-7554-3438)
- Liang Peng (ORCID: https://orcid.org/0000-0001-6184-5750)
- Yuyu Ye
- Jing Cai (ORCID: https://orcid.org/0000-0003-4128-572X)
- Wei Song (ORCID: https://orcid.org/0000-0003-3756-198X)
- Ying Liu (ORCID: https://orcid.org/0000-0003-3672-9621)
- Guangmei Yan (ORCID: https://orcid.org/0000-0002-8822-2657)
- Yuan Lin (ORCID: https://orcid.org/0000-0002-7152-0965)
- Jingjie Li (ORCID: https://orcid.org/0000-0002-1605-0518)
- Wenbo Zhu (ORCID: https://orcid.org/0000-0002-9143-5733)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1623211
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province