Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and Mycoplasma bovis-challenged bison

The greatest number of differentially expressed transcripts (DETs) (≤0.05 FDR) were found in blood at 36 DPV (123 total DETs) and in spleen (57 DETs). At 36 DPV, vaccinated animals showed upregulation of transcripts involved in in cell adhesion, T-helper cell (Th1/Th2/Th17) differentiation, and antigen processing and presentation. This signifies a robust response to the 2nd vaccine dose, which caused increased expression of <i>CD3E</i>, <i>CD4</i>, and <i>CD8B</i> correlating to increased T cell proliferation. Notably, transcription factors <i>TBX21</i> and <i>GATA3</i> were upregulated in vaccinated animals. Spleen-specific regulation included transcripts involved in innate immune response, such as <i>LGALS3</i> and <i>GBP-1</i>. These findings highlight the robust immune response induced by the vaccine, particularly through T-cell mediated responses, demonstrating its potential to enhance protective immunity against <i>M. bovis</i> in bison.

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Publication Details

Journal
Frontiers in Veterinary Science
Published
2025-09-16
DOI
https://doi.org/10.3389/fvets.2025.1667623
Citations
1
Primary Topic
Microbial infections and disease research
Type
article
Field-Weighted Citation Impact
1.18

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article

Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and Mycoplasma bovis-challenged bison

Eduardo Casas, Carly Kanipe, Paola Mercedes Boggiatto, Anna K. Goldkamp et al.
1 citations
Frontiers in Veterinary Science
Microbial infections and disease research
1.18
article

Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and Mycoplasma bovis-challenged bison

Eduardo Casas, Carly Kanipe, Paola Mercedes Boggiatto, Anna K. Goldkamp, Lauren S. Crawford, Harish Menghwar, Steven C. Olsen, Rohana P. Dassanayake, Fred M. Tatum, Robert E. Briggs, Bryan S. Kaplan
article en
1 citations

Abstract

The greatest number of differentially expressed transcripts (DETs) (≤0.05 FDR) were found in blood at 36 DPV (123 total DETs) and in spleen (57 DETs). At 36 DPV, vaccinated animals showed upregulation of transcripts involved in in cell adhesion, T-helper cell (Th1/Th2/Th17) differentiation, and antigen processing and presentation. This signifies a robust response to the 2nd vaccine dose, which caused increased expression of <i>CD3E</i>, <i>CD4</i>, and <i>CD8B</i> correlating to increased T cell proliferation. Notably, transcription factors <i>TBX21</i> and <i>GATA3</i> were upregulated in vaccinated animals. Spleen-specific regulation included transcripts involved in innate immune response, such as <i>LGALS3</i> and <i>GBP-1</i>. These findings highlight the robust immune response induced by the vaccine, particularly through T-cell mediated responses, demonstrating its potential to enhance protective immunity against <i>M. bovis</i> in bison.

Frontiers in Veterinary ScienceVol. 12
Oak Ridge Associated Universities (US), Agricultural Research Service (US), United States Department of Agriculture (US), National Animal Disease Center (US), Oak Ridge Institute for Science and Education
U.S. Department of Agriculture, Agricultural Research Service
Openalex Percentile: Top 18%
Microbial infections and disease research
1.18
DOIOpen Access PDFOpenAlex
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