Luteolin improves the systolic and diastolic functions of the thoracic aortic vessels in type 2 diabetic rats through the Kv7.1 channel
Luteolin improves vascular tone and function in diabetic rats by restoring Kv7.1/KCNQ1 expression, possibly through inhibition of PKC signaling. These findings highlight Kv7.1 as a potential therapeutic target for diabetic vascular complications.
Authors
- Haijie Ji
- Xiaojia Xu (ORCID: https://orcid.org/0000-0003-2621-1618)
- Li Wu (ORCID: https://orcid.org/0000-0002-8469-514X)
- Pengmei Guo
- Xingru Wang (ORCID: https://orcid.org/0000-0002-7092-8328)
- Weiping Li (ORCID: https://orcid.org/0000-0002-5534-5925)
- Zhen Yang (ORCID: https://orcid.org/0000-0002-9314-3590)
- Y B Lyu (ORCID: https://orcid.org/0000-0002-8912-6624)
- Yanru Wang (ORCID: https://orcid.org/0000-0002-3244-7806)
Institutions
- Shanxi University (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Shanxi Fenyang Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fphar.2025.1651847
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00